Abstract #4944

Investigating tissue oxygenation in acute Traumatic Brain Injury using Arterial Spin Labelling and quantitative-BOLD

Alan J Stone¹, Tim P Lawrence^1,2, Thomas W Okell¹, Natalie L Voets^1,2, and Nicholas P Blockley¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Following a traumatic brain injury, oxygen metabolism may be disrupted by changes in oxygen supply and demand. This study aims to investigate global changes in oxygen metabolism in the hours immediately following the initial insult to the brain. Pseudo-continuous ASL (PCASL) and streamlined-qBOLD (sqBOLD) are used to measure blood flow and oxygenation in the acute stages of TBI (<24 hours post-injury). When compared with an age matched control group, blood oxygenation appears to increase during injury (decreased OEF (p=0.03)) at this acute time-point.

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