Conventional DTI readouts such as fractional anisotropy (FA), axial diffusion (RD) and radial diffusion (RD) show distinct alterations following closed head injury but do not correlate well with measured functional and cognitive outcomes. 3D DTI with parcellated connectome analysis reveals neural fiber networks between brain regions that are most vulnerable to closed head (acceleration-deceleration) injury and also most relevant to measurable functional deficits. In this study, fiber tract number between hippocampus and cortex is the most sensitive marker of both motor and memory deficits and therapeutic improvement following administration of a novel neuroprotective therapeutic agent.
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