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Abstract #4946

Working Memory And White Matter Microstructure In Mild Traumatic Brain Injury

Sohae Chung1, Els Fieremans1, Xiuyuan Wang1, Charles J Morton1, Dmitry S Novikov1, Joseph F Rath2, and Yvonne W Lui1

1Center for Advanced Imaging Innovation and Research (CAI2R) & Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Department of Rehabilitation Medicine, NYU School of Medicine, New York, NY, United States

Working memory is a critical cognitive function implicated after mild traumatic brain injury (MTBI). Here, we investigate the association between white matter microstructure and working memory in normal controls (NC) and MTBI patients, using diffusion white matter tract integrity (WMTI) and WAIS-IV subtests, respectively. For the NC group, significant correlations were observed in axonal water fraction (AWF; higher axonal density/myelination) and mean kurtosis (MK; greater tissue complexity) with letter-number sequencing (LNS). However, such relationships were not present in the MTBI group.

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