Abstract #4951

Transient neuronal dysfunction correlates with hypo-perfusion in patients with moderate post-traumatic brain injury

Eva-Maria Ratai^1,2, Suk-tak Chan^2,3, Maria Gabriela Figueiro Longo⁴, Michael Wenke¹, Termara Parker¹, Jonathan Welt^2,5, Joyce van Loon⁴, Emad Ahmadi¹, Anastasia Yendiki^2,3, Jacqueline Namati^2,5, Isabel Chico-Calero^2,5, Blair Parry⁶, Can Ozan Tan^2,7, Jarone Lee^2,8, Michael Lev^2,9, Michael Hamblin^2,5, Benjamin Vakoc^2,5, and Rajiv Gupta^1,2

¹Department of Radiology / Neuroradiology Division, Massachusetts General Hospital/ A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Radiology, Massachusetts General Hospital/ A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States, ⁶Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States, ⁷Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation, Charlestown, MA, United States, ⁸Department of Emergency Medicine and Department of Surgery, Massachusetts General Hospital, Boston, MA, United States, ⁹Emergency Radiology and Emergency Neuroradiology, Massachusetts General Hospital, Boston, MA, United States

We present a DOD funded study to assess the effects of low-level light therapy (LLLT) on metabolites measured by MRS and cerebral perfusion measured by ASL using a double-blind, placebo controlled study where patients with moderate TBI were randomized between LLLT and sham treatment. We report CBF and metabolic changes pertaining to neuronal injury and neuroinflammation for the entire cohort (i.e., both treated and control arms), before the blind is broken. Our findings suggest that transient neuronal dysfunction in the posterior cingulate cortex and neuroinflammation in the thalamus correlated with hypo-perfusion during the subacute phase of moderate TBI.

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