Abstract #4954

Low-frequency Fluctuations of Resting-state fMRI BOLD Signal after Experimental Mild Traumatic Brain Injury

Yu-Chieh Jill Kao^1,2, Chia-Feng Lu^1,3, Ping-Huei Tsai^1,2, Fei-Ting Hsu^1,2, Bao-Yu Hsieh⁴, and Cheng-Yu Chen^1,2

¹Research Center of Translational Image, Teipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁴Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

Regional amplitude of rsfMRI BOLD signal after mTBI was quantified using amplitude of low-frequency fluctuation (ALFF). The significant increase of ALFF around the impact regions at 24 h and renormalized at 50 days after mTBI may suggest the dynamics of neuronal activity and neurovascular response induced by the injury.

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