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Abstract #4955

Altered Functional Connectivity and Network Topology in Active Profession Fighters

Karthik R Sreenivasan1, Zhengshi Yang1, Virendra Mishra1, Sarah Banks1, Dietmar Cordes1,2, and Charles Bernick1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

Studies have shown that both active and retired athletes with repeated head trauma are more likely to suffer from cognitive decline and loss of executive and attention functions when compared to age- matched healthy controls. Our results show decreased functional connectivity in the active fighter group when compared to controls between regions known to be implicated in traumatic brain injury. Furthermore, we found a shift towards a less efficient network topology with altered integration and segregation in active professional fighters.

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