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Abstract #4956

GlucoCEST weighted MRI detects metabolic abnormalities following experimental TBI on 7T and 9.4T

Tsang-Wei Tu1,2, Jaclyn Witko2, and Joseph Frank2

1Howard University, Washington, DC, United States, 2National Institutes of Health, Bethesda, MD, United States

Delayed glucose hypometabolism has been reported in traumatic brain injury (TBI) patients from weeks to years posing a high risk for neurodegenerative diseases. This study shows the feasibility of glucoCEST weighted MRI (GWI) to detect metabolic abnormalities following TBI on 7T and 9.4T. The GWI results were compared to 2DG autoradiography and immunohistochemitry indicating that the injured brain needed immediate energy to restore nervous function and then entered a hypometabolism state in week 2. GWI affords the sensitivity to detect cerebral metabolic states following TBI and has potential to identify the treatment window to increase neuronal survival.

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