Abstract #4958

Gray matter volume changes following Cranial Nerve Non-invasive NeuroModulation in patients with traumatic brain injuries

Jiancheng Hou¹, Arman Kulkarni², Neelima Tellapragada¹, Veena Nair¹, Mitch Tyler^2,3, Yuri Danilov³, Kurt Kaczmarek³, Beth Meyerand², and Vivek Prabhakaran¹

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States

The main conventional approach for treating traumatic brain injury related gait and balance deficits has been through physical therapy, but few approaches have focused on brain based rehabilitation efforts that create direct neuroplastic changes. There remains a need for such an approach. Therefore, the goal of this study was: 1) to apply Cranial Nerve Non-Invasive NeuroModulation (CN-NINM) via the tongue in combination with multiple symptom-specific physical therapy exercises in patients with mild to moderate TBI, and 2) to investigate and quantify gray matter volume changes prior to and after intervention as well as their correlation with behavior.

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