Meeting Banner
Abstract #4962

ASL-based fMRI phenotyping of high-anxiety Fischer rat strain reveals two unexpected sub-traits or -states: caveat for rodent studies

Andreas Bruns1, Thomas Mueggler1, Markus von Kienlin1, and Basil K√ľnnecke1

1Roche Pharma Research & Early Development, Neuroscience Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Fischer rats serve as a rodent model of high trait anxiety in neuroscience and drug discovery. Using ASL-based fMRI, we characterized Fischer rats with respect to their regional brain activity patterns and with reference to the standard Sprague-Dawley rat strain. Fischer rats clearly differed from Sprague-Dawley rats, but also split into two distinct subpopulations, with one showing a more deviant pattern than the other. Although it has remained elusive whether this is a trait or a state phenomenon, our data suggest that neuronal networks related to anxiety and/or depression are implicated.

This abstract and the presentation materials are available to members only; a login is required.

Join Here