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Abstract #4961

Hippocampal-Cerebellar metabolic investigation in TBI rats: NMR spectroscopy study

Subash Khushu1, Kavita Singh1, Richa Trivedi1, Sonia Gandhi1, and Poonam Rana1

1NMR Research Centre, Institute of Nuclear Medicine & Allied Sciences(INMAS), DELHI, India

Cerebellar atrophy and dysfunction has been reported in clinical TBI. hippocampal-cerebellar cognitive collaborations and its manifestation in TBI is being reported. This study investigated TBI mediated metabolic irregularities in CB and HP in animal model of TBI. These results indicated that CB and HP are metabolically different regions. The models generated from the changes due to trauma could accurately discriminate CB and HP and injury severity. We speculate that reduced NAA and Cho levels may be due to substantial focal neuronal loss after weight drop TBI. Edema and excitotoxity following injury leads to altered levels of osmolytes and Glu/Gln.

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