Abstract #4960

Assessment of metabolic changes in traumatic brain injury using hyperpolarized [1-13C]pyruvate: a longitudinal study

Edward Hackett¹, Laura Ingle², Brenda Bartnik-Olson³, and Jae Mo Park¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Radiology, Loma Linda University, Loma Linda, CA, United States

In this study, we longitudinally assessed acute metabolic changes during 2-120hrs post traumatic brain injury in a controlled-cortical impact rat model using hyperpolarized [1-¹³C]pyruvate. We observed mildly increased pyruvate conversion to lactate and significantly reduced bicarbonate production in the injured site at 24hrs after impact. Conversely, lactate was reduced when measured at 48hrs-post injury. Bicarbonate production in the lesion remained low with significantly increased bicarbonate production in the contralateral normal-appearing brain

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