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Abstract #4970

Transient hyperhydration modulates the brain fluid distribution of spontaneous hypertension rats: A T2 relaxometry study

Kun-I Chao1, Xia-Yu Lyu1, Pei-Lun Yu1, Sheng-Min Huang1, Shin-Lei Peng2, Kung-Chu Ho3, Ping-Huei Tsai4, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 3Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 4Department of Radiology, Taipei Medical University Hospital, Taipei, Taiwan

After 2% of body weight fluid infusion, the homeostasis of fluid distribution was temporally modulated in spontaneously hypertensive rats, which is an animal model of neurodegenerative disease. After fluid infusion, shortened T2 showed in hippocampus and ventricles, and prolonged T2 was in corpus callosum and amygdala. The analysis of T2 distribution with rNNLS showed that a component with T2 around 100-200ms was increased in both T2-altered regions. We attributed this component as a restricted interstitial fluid, which could be correlated to the function of glymphatic system. Therefore, our experiment may shed a light on functional imaging of glymphatic system.

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