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Abstract #4969

Synaptic Basis for Remodeling in the Mouse Somatosensory System Characterized by fMRI

Emily Petrus1, Galit Saar1, Zhiwei Ma1, Steve Dodd1, and Alan Koretsky1

1Laboratory of Functional and Molecular Imaging, National Institutes of Health, NINDS, Bethesda, MD, United States

Functional MRI (fMRI) is an effective tool to analyze brain activity, with research and clinical implications. Here we describe changes in fMRI stimulus evoked BOLD responses after unilateral whisker denervation in adult mice. These effects were mediated by specific synaptic remodeling in the whisker somatosensory system. Our results indicate that fMRI can detect circuit level changes in vivo, which can then be characterized at the synaptic level in vitro.

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