Abstract #4968

Tomoelastography of the mouse brain by multifrequency single-shot MR elastography

Gergely Bertalan¹, Jing Guo¹, Heiko Tzschätzsch¹, Charlotte Klein², Jürgen Braun³, and Ingolf Sack¹

¹Department of Radiology, Charité - University Medicine Berlin, Berlin, Germany, ²Department of Neurology, Charité - University Medicine Berlin, Berlin, Germany, ³Department of Medical Informatics, Charité - University Medicine Berlin, Berlin, Germany

The overall aim of this study was to introduce in-vivo multifrequency single-shot MR elastography (MRE) for full-field-of-view stiffness mapping of mouse brain and to compare in-vivo stiffness of neural tissues featuring different white-to-gray matter ratios. Tomoelastography retrieves mouse brain stiffness with greater detail. The measured order of shear vave speed values indicates that white matter in the mouse brain is softer than gray matter within the examined frequency range from 900 to 1400 Hz.

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