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Abstract #4967

Assignment of Two More Fucose-α-(1-2)-Galactose Glycans in the Human Brain Linked in Animal Models to Learning and Memory

Nathan Tosh1,2, Scott Quadrelli1,3, Graham Galloway1, and Carolyn Mountford1

1Translational Research Institute, Brisbane, Australia, 2Faculty of Health, Queensland University of Technology, Brisbane, Australia, 3University of Newcastle, Newcastle, Australia

Two-dimensional COSY scans at 3T using a 64 channel head and neck coil have enabled the inspection of fucose-α-(1-2)-galactose glycans that resonate in the region of F1=0.9-1.7ppm; F2= 4.1-4.5ppm. With accurate shimming and water suppression, two new peaks were identified (Fuc VI at 4.44-1.37 ppm and Fuc VII at 4.29-1.36 ppm). These cross-peaks were consistently visualised across 86 participants.

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