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Abstract #4966

Orbitofrontal-limbic structural development maturation in non-human primates: a longitudinal study

Akiko Uematsu1,2,3, Junichi Hata1,3,4, Yuji Komaki3, Fumiko Seki1,3,4, Chihoko Yamada3, Norio Okahara3, Yoko Kurotaki3, Erika Sasaki1,3,4, and Hideyuki Okano1,4

1Keio University School of Medicine, Tokyo, Japan, 2RIKEN BSI Laboratory for Marmoset Neural Architecture, Saitama, Japan, 3Central Institute for Experimental Animals, Kawasaki, Japan, 4RIKEN BSI, Saitama, Japan

We investigated typical orbitofront-limbic structural development of a non-human primate model, common marmoset, using longitudinal MRI data. Overall, robust volumetric growth was observed during infancy. This rapid brain volumetric growth was associated with the largest decrease in diffusivities of diffusion tensor imaging. That suggest that the volume increment result from an increase in the number and size of cells, dendrites, and spines in the regions. In addition, our result suggested familial factors contributed the development of the orbitofrontal-limbic brain regions. Overall, this study provides further data on the factors and timing important for typical brain development.

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