Abstract #4974

In Vivo Mapping and Quantification Approaches in Epileptic Seizure Rat Models Using Creatine Chemical Exchange Saturation Transfer (CrCEST) Imaging

Dong-Hoon Lee¹, Do-Wan Lee², Jae-Im Kwon³, Chul-Woong Woo³, Sang-Tae Kim³, Jin Seong Lee⁴, Choong Gon Choi⁴, Kyung Won Kim⁴, Jeong Kon Kim⁴, and Dong-Cheol Woo^5,6

¹Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia, ²Center for Bioimaging of New Drug Development, and MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, ³MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, ⁴Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁵MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁶Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

CrCEST imaging is a novel imaging technique to provide in vivo image contrasts related with the changes of energy metabolism by creatine level changes. In this abstract, we attempted to evaluate signal changes in hippocampus at epileptic seizure rat models based on the quantified CrCEST signals. We also analyzed the correlations between CrCEST signals and PCr and PCr+Cr concentrations assessed by ¹H-MRS spectra. Our results clearly showed that the CrCEST imaging can be a useful approach to evaluate the energy metabolism in hippocampus at epileptic seizure model, and to provide the quantitative results that related with creatine level changes.

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