Abstract #4975

Chemical Exchange Saturation Transfer Imaging of Glutamate (GluCEST) in a Rat Model of Epilepsy using Proton Magnetic Resonance Spectroscopy (1H-MRS) at 7T

Do-Wan Lee¹, Jae-Im Kwon², Dong-Hoon Lee³, Chul-Woong Woo², Sang-Tae Kim², Jin Seong Lee⁴, Choong Gon Choi⁴, Kyung Won Kim⁴, Jeong Kon Kim⁴, and Dong-Cheol Woo^5,6

¹Center for Bioimaging of New Drug Development, and MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, ²MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, ³Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia, ⁴Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁵MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁶Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Chemical exchange saturation transfer imaging of glutamate (GluCEST) is a novel magnetic resonance imaging (MRI) method for measuring brain glutamate (Glu) in humans and animals. In vivo quantification of neurotransmitter signals can provide insight into functional roles of brain structures and knowledge about biochemical compounds. This study, based on quantified GluCEST contrast values and ¹H-MR spectral concentrations, assessed signal changes in control rats and rats with kainic acid-induced epileptic seizures, and showed that in vivo GluCEST and ¹H-MR spectral data can provide valuable information for interpreting changes in signals and concentrations of specific cerebral metabolites in kainic acid-induced rats.

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