Abstract #4976

Correlations between brain metabolites and tau protein accumulation assessed by H-MRS and tau PET in Alzheimer’s disease model mice

Yuhei Takado¹, Hiroyuki Takuwa¹, Urushihata Takuya¹, Manami Takahashi¹, Maiko Ono¹, Jun Maeda¹, Masafumi Shimojo¹, Nobuhiro Nitta², Sayaka Shibata², Ichio Aoki², Naruhiko Sahara¹, Tetsuya Suhara¹, and Makoto Higuchi¹

¹Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

Amyloid beta protein and tau proteins are two major hallmarks of the pathology of Alzheimer’s disease. To elucidate the relationship between brain metabolites and tau protein, we performed H-MRS and tau PET imaging of tauopathy mouse model (rTg4510). Five rTg4510 mice and five wild-type mice were scanned at the age of 4 and 6 months by H-MRS and tau PET. We demonstrated that the amount of tau had negative correlations with the amount of taurine, tNAA, and glutamate, indicating that tau might reduce those metabolites selectively and caused neural impairment.

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