Meeting Banner
Abstract #4983

Diffusion Basis Spectrum Imaging (DBSI): Successful in vivo Use to Assess Axonal Protection in Mouse Optic Neuritis treated with Fingolimod

Tsen-Hsuan (Abby) Lin1, Rui-Meng Yang1,2, Jie Zhan 1,3, Chunyu Song4, Peng Sun1, Michael Wallendorf5, Anne H Cross6,7, and Sheng-Kwei Song1,4,7

1Radiology, Washington University School of Medicine, St Louis, MO, United States, 2Radiology, Guangzhou Medical University, Guangzhou, China, 3Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China, 4Biomedical Engineering, Washington Univerisyt is St. Louis, St Louis, MO, United States, 5Biostatistics, Washington University School of Medicine, St Louis, MO, United States, 6Neurology, Washington University School of Medicine, St Louis, MO, United States, 7Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, United States

We previously introduced diffusion basis spectrum imaging (DBSI) to noninvasively assess coexisting pathologies in central nervous system (CNS) tissues.Previously, we showed in multiple sclerosis (MS) spinal cord specimens and mice with experimental autoimmune encephalomyelitis (EAE), the main animal model of MS, that DBSI reflected coexisting white matter pathologies in CNS. Fingolimod, a disease-modifying treatment approved for relapsing MS, is thought to preserve axons. In the current study, we employed longitudinal DBSI to noninvasively assess fingolimod treatment efficacy in EAE mouse optic nerve, followed by histological validation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords