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Abstract #4984

Protein Aggregation in Mouse Brain with Alzheimer's Disease Revealed by Saturation Transfer MRI

Lin Chen1,2,3, Zhiliang Wei2,3, Kannie Chan2,3,4, Shuhui Cai1, Guanshu Liu2,3, Hanzhang Lu2,3, Philip C. Wong5, Peter C.M. van Zijl2,3, Tong Li5, and Jiadi Xu2,3

1Department of Electronic Science, Xiamen University, Xiamen, China, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 4Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 5Department of Pathology, Johns Hopkins University, Baltimore, MD, United States

This study aims to detect the aggregated proteins involved in Alzheimer's Disease (AD) using chemical exchange saturation transfer (CEST) as a potential strategy for early diagnosis of the disease. A radial ultra-short echo time (UTE) image acquisition scheme was applied to map CEST signals with sufficient sensitivity and robustness to motion. Studies on cross-linked bovine serum albumin (BSA) and an AD transgenic model (mutant APP/PS1 mouse) demonstrated that the saturation transfer (ST) signal at -3.6 ppm, which is a combination of relayed nuclear Overhauser enhancement (rNOE)-CEST and a small portion of magnetization transfer contrast (MTC), can be used a potential biomarker for monitoring changes in brains of a mouse model of AD.

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