Abstract #4984

Protein Aggregation in Mouse Brain with Alzheimer's Disease Revealed by Saturation Transfer MRI

Lin Chen^1,2,3, Zhiliang Wei^2,3, Kannie Chan^2,3,4, Shuhui Cai¹, Guanshu Liu^2,3, Hanzhang Lu^2,3, Philip C. Wong⁵, Peter C.M. van Zijl^2,3, Tong Li⁵, and Jiadi Xu^2,3

¹Department of Electronic Science, Xiamen University, Xiamen, China, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁵Department of Pathology, Johns Hopkins University, Baltimore, MD, United States

This study aims to detect the aggregated proteins involved in Alzheimer's Disease (AD) using chemical exchange saturation transfer (CEST) as a potential strategy for early diagnosis of the disease. A radial ultra-short echo time (UTE) image acquisition scheme was applied to map CEST signals with sufficient sensitivity and robustness to motion. Studies on cross-linked bovine serum albumin (BSA) and an AD transgenic model (mutant APP/PS1 mouse) demonstrated that the saturation transfer (ST) signal at -3.6 ppm, which is a combination of relayed nuclear Overhauser enhancement (rNOE)-CEST and a small portion of magnetization transfer contrast (MTC), can be used a potential biomarker for monitoring changes in brains of a mouse model of AD.

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