Abstract #4985

Atlas-based and voxel-based symptom mapping to explore anatomical substrates of functional recovery after stroke in the mouse

Stefan Paul Koch^1,2, Felix Knab¹, Ulrike Grittner¹, René Bernard¹, Susanne Mueller^1,2, Marco Foddis¹, Janet Lips¹, Philipp Euskirchen¹, Norman Zerbe³, Peter Hufnagl³, André Rex¹, Ulrich Dirnagl¹, Tracy Deanne Farr⁴, Christoph Harms¹, and Philipp Boehm-Sturm^1,2

¹Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, ²Cluster of Excellence NeuroCure and Charité Core Facility 7T Experimental MRIs, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Institute of Pathology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Post-stroke functional recovery remains a poorly understood process. We aimed to identify anatomical regions that statistically explain a deficit in the staircase test after stroke in the mouse using two animal models (MCAO, photothrombosis). MATLAB toolboxes are presented for co-registration of MRI and histology data to the Allen brain atlas and implementation of atlas region-wise or voxel-wise mapping of behavioral deficits. Automatic techniques are shown for validation of MRI results on stained tissue sections.

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