Meeting Banner
Abstract #4985

Atlas-based and voxel-based symptom mapping to explore anatomical substrates of functional recovery after stroke in the mouse

Stefan Paul Koch1,2, Felix Knab1, Ulrike Grittner1, René Bernard1, Susanne Mueller1,2, Marco Foddis1, Janet Lips1, Philipp Euskirchen1, Norman Zerbe3, Peter Hufnagl3, André Rex1, Ulrich Dirnagl1, Tracy Deanne Farr4, Christoph Harms1, and Philipp Boehm-Sturm1,2

1Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, 2Cluster of Excellence NeuroCure and Charité Core Facility 7T Experimental MRIs, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Institute of Pathology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 4School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Post-stroke functional recovery remains a poorly understood process. We aimed to identify anatomical regions that statistically explain a deficit in the staircase test after stroke in the mouse using two animal models (MCAO, photothrombosis). MATLAB toolboxes are presented for co-registration of MRI and histology data to the Allen brain atlas and implementation of atlas region-wise or voxel-wise mapping of behavioral deficits. Automatic techniques are shown for validation of MRI results on stained tissue sections.

This abstract and the presentation materials are available to members only; a login is required.

Join Here