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Abstract #5003

Quantitative Susceptibility Mapping of Articular Cartilage in Patients with Osteoarthritis

Hongjiang Wei1, Huimin Lin2, Yuyao Zhang1, Weibo Chen3, Fuhua Yan2, and Chunlei Liu1

1University of California, Berkeley, Berkeley, CA, United States, 2Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, Shanghai, China

Osteoarthritis (OA) is a multifactorial degenerative joint disease and is the most common form of arthritis which characterized by degenerative changes in the cartilage, menisci, ligaments and bone. The purpose of this study is to evaluate the magnetic susceptibility changes in knee diseases, such as patients with bone marrow lesions and cartilage loss. Clear susceptibility contrast was observed between bone marrow lesions and surroundings. The multilayer pattern of the damaged cartilage was lost compared with that of healthy subjects. QSM may provide a new way to improve the characterization of tissue microstructure in the knee joint related to osteoarthritis.

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