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Abstract #5005

Imaging Human Brain Cortical Substructure with Quantitative Susceptibility Mapping at 7 T

Hongjiang Wei1, Berkin Bilgic2, Kawin Setsompop2, Boris Keil2, David Feinberg 3,4, and Chunlei Liu1,3

1EECS, University of California, Berkeley, Berkeley, CA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Helen Wills Institute for Neuroscience, University of California, Berkeley, Berkeley, CA, United States, 4Advanced MRI Technologies, Sebastopol, CA, United States

High-field MRI combined with high-density motor-cortex coil and a novel QSM algorithm allows in vivo brain cortex imaging with high contrast-to-noise ratio and spatial resolution (0.15x0.15x0.65 mm3). Our work revealed up to six apparent myelin/iron layers in human cortex in vivo determined by the underlying magnetic susceptibility and complex vasculature in the cortical areas. Cortical susceptibility imaging provides high-resolution quantitative measurements of cortical cytoarchitecture and vasculature.

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