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Abstract #5010

Gadoxetate relaxivities increase significantly after hepatic uptake at clinical field strength impacting kinetic modelling for liver function analysis

Gregor Jost1, Gunnar Schuetz1, and Hubertus Pietsch1

1MR & CT Contrast Media Research, Bayer AG, Berlin, Germany

Schuhmann-Giampieri1 reported r1 of gadoxetate to be significantly higher in liver tissue compared to blood at 0.47T. Gadoxetate relaxivities at 1.5T, 3T and 4.7T have since then been reported for water and plasma2, but not hepatocytes. We here present r1 values for gadoxetate in hepatocytes at 1.5T and 3T to complement existing data. r1 values of gadoxetate after uptake into hepatocytes are about 2x higher compared to blood. There is no relevant field strength dependency over a wide range (0.47T - 3T). This has implications on kinetic modelling of dynamic gadoxetate enhanced MRI data for determination of liver transporter activity.

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