Meeting Banner
Abstract #5011

Exploring the Origin of Asymmetries in the Balanced SSFP Profile at 9.4 Tesla: Microstructure Anisotropy or Chemical Exchange?

Rahel Heule1, Moritz Zaiss1, Philipp Ehses2, and Klaus Scheffler1,3

1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2German Center for Neurodegenerative Diseases, Bonn, Germany, 3Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

The balanced steady-state free precession (bSSFP) profile is known to carry information about the tissue-dependent frequency content in a voxel. There has been strong evidence that the observed asymmetries in the bSSFP profile of white matter depend on the tract orientation with the largest asymmetries occurring in tracts perpendicular to B0. Recently, it was demonstrated that the bSSFP sequence can be used for chemical exchange detection based on profile asymmetries arising in isotropic probes of two exchanging pools. In this work, we explore the question whether exchanging species might contribute to the bSSFP profile asymmetry observed in white matter.

This abstract and the presentation materials are available to members only; a login is required.

Join Here