A novel dinuclear gadolinium(III) chelate containing two moieties of DTPA, covalently conjugated to deoxycholic acid is presented. The product was synthesized and characterized in vitro (analysis of relaxometric properties in different media) and in vivo (blood pharmacokinetic and MRI bio-distribution). The complex showed a much higher relaxivity than Gd-DTPA and other dinuclear complexes proposed in literature. Moreover, it displayed a strong interaction with human serum albumin in three binding sites. This property translates in a long blood elimination half time (130min in rats) making the product an optimal blood-pool agent.
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