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Abstract #5018

NOE contributions to the z-spectrum of human blood

Andrew John Carradus1, Simon Shah1, Olivier Mougin1, Hans Hoogduin2, and Penny Gowland1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

This study investigates the properties of relayed NOE effects in the blood by fitting z-spectra acquired using continuous wave saturation to the analytical solutions of the Bloch-McConnel equations. We systematically model for an increasing number of NOE peaks based on previous reports, and find that adding in two NOE peaks at -3.5ppm and -1.7ppm significantly improves the fit, but adding further peaks does not. Furthermore, we fit for the exchange rates and T2s of these pools, and find that the peak at -3.5ppm has exchange rate=21.5Hz and T2=0.9ms and the peak at -1.7 ppm has exchange rate=8.6Hz and T2=3ms.

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