Abstract #5018

NOE contributions to the z-spectrum of human blood

Andrew John Carradus¹, Simon Shah¹, Olivier Mougin¹, Hans Hoogduin², and Penny Gowland¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

This study investigates the properties of relayed NOE effects in the blood by fitting z-spectra acquired using continuous wave saturation to the analytical solutions of the Bloch-McConnel equations. We systematically model for an increasing number of NOE peaks based on previous reports, and find that adding in two NOE peaks at -3.5ppm and -1.7ppm significantly improves the fit, but adding further peaks does not. Furthermore, we fit for the exchange rates and T₂s of these pools, and find that the peak at -3.5ppm has exchange rate=21.5Hz and T₂=0.9ms and the peak at -1.7 ppm has exchange rate=8.6Hz and T₂=3ms.

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