Meeting Banner
Abstract #5019

Non-rigid atlas registration for improved quantitative assessment of rat brain regions with limited inherent anatomical contrast

Matthew Tarasek1, Jeannette Roberts2, Deirdre Cassidy 3, Desmond Yeo1, Randall Carter2, and Brian Bales2

1MRI, GE Global Research, Niskayuna, NY, United States, 2Life Sciences, GE Global Research, Niskayuna, NY, United States, 3Life Sciences, GE Healthcare UK, United Kingdom, United Kingdom

We present a method for 3D non-rigid, feature-based atlas registration to images that contain limited inherent anatomical MR contrast. This method can be used to standardize ROI identification and may be applied to any multi-functional imaging technique to provide increased quantitative registration accuracy. Here quantitative T1 measurements were used to test the accuracy and reproducibility of the method. Overall, data analysis performed with atlas registration provides a 2-fold reduction in standard deviation and 4-fold increase in reproducibility versus data analysis performed without registration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here