Abstract #5020

Phenols as Diamagnetic T2-exchange Magnetic Resonance Imaging Contrast Agents

Jia Zhang¹, Yuguo Li¹, Stephania Slania², Nirbhay Yadav^1,3, Jing Liu¹, Rongfu Wang⁴, Jianhua Zhang⁴, Martin Pomper¹, Peter van Zijl^1,3, Xing Yang^1,4, and Guanshu Liu^1,3

¹Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Nuclear Medicine, Peking University First Hospital, Beijing, China

To further explore the ability of using diamagnetic compounds for generating MRI contrast, we chose phenol as a model compound and systematically characterized its T₂-exchange (T_2ex) ability. We designed a library of phenol-based compounds and determined the effects of chemical modification on their proton exchange rate (k_ex) and chemical shift (∆ω) and consequently, their T_2ex contrast. A large ∆ω is favorable for generating strong T_2ex contrast, while there is an optimal k_ex at each specific ∆ω. Finally, as an example of biomedical application, we demonstrated the label-free detection of tyrosinase activity using T_2ex MRI.

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