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Abstract #5020

Phenols as Diamagnetic T2-exchange Magnetic Resonance Imaging Contrast Agents

Jia Zhang1, Yuguo Li1, Stephania Slania2, Nirbhay Yadav1,3, Jing Liu1, Rongfu Wang4, Jianhua Zhang4, Martin Pomper1, Peter van Zijl1,3, Xing Yang1,4, and Guanshu Liu1,3

1Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Nuclear Medicine, Peking University First Hospital, Beijing, China

To further explore the ability of using diamagnetic compounds for generating MRI contrast, we chose phenol as a model compound and systematically characterized its T2-exchange (T2ex) ability. We designed a library of phenol-based compounds and determined the effects of chemical modification on their proton exchange rate (kex) and chemical shift (∆ω) and consequently, their T2ex contrast. A large ∆ω is favorable for generating strong T2ex contrast, while there is an optimal kex at each specific ∆ω. Finally, as an example of biomedical application, we demonstrated the label-free detection of tyrosinase activity using T2ex MRI.

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