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Abstract #5021

Nanomicelles – A Blood Pool Contrast Agent for MRI

Vassily Vorobiev1, Lindsey Alexandra Crowe2, Yohan van de Looij3,4,5, Lothar Helm6, Samuel Espy1, Andrej Babič1, Jean-Paul Vallée2, and Eric Allémann1

1School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland, 2Division of Radiology, Geneva University Hospitals, Geneva, Switzerland, 3Institut Translationnel d'Imagerie Moléculaire, University of Geneva, Geneva, Switzerland, 4Service Développement et Croissance, University of Geneva, Geneva, Switzerland, 5Laboratoire d'Imagerie Fonctionnelle et Métabolique, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Group of Inorganic and Bioinorganic Chemistry, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

A blood pool MRI contrast agent for free breathing MR angiography is highly desirable in particular for pediatric cardiovascular exams in order to improve both image quality and patient comfort. Apnea in infants and be propofol induced, or via intubation, which is invasive and limits acquisition to short protocols. We present here initial in-vivo studies in mice of a newly developed nanomicelles gadolinium contrast agent. Persistent vascular enhancement is observed with no toxicity. Micelles also open the way to functionalization for theranostic applications.

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