Abstract #5025

High rotating frame relaxation MRI mapping for detecting ischemia in rats

Eleni Demetriou¹, Hanne Laakso², Timo Liimatainen³, Silvia Mangia², Shalom Michaeli², and Xavier Golay⁴

¹Brain repair and rehabilitation, University College of London, London, United Kingdom, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Diagnostic Imaging Canter, Kuopio University Hospital, Kuopio, Finland, ⁴Brain Repair and Rehabilitation, University College of London, London, United Kingdom

The goal of this work is to evaluate novel MRI technique entitled Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank n (RAFFn, with n=4) in its ability to detect ischemia, specifically when tuning the sensitivity of RAFF4 to exchange processes of amide protons. Relaxation maps were thus measured in healthy and infarcted rats at 24h post stroke, and were compared with other conventionally used quantitative MRI modalities. RAFF4 robustly detected infarcted regions with enhanced contrast as compared to T1 relaxation and MTR asymmetry, thus offering a sensitive novel MRI marker for quantifying tissue abnormalities during ischemia.

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