D2O is a freely diffusible trace for calculating blood flow and give more accurate than limited diffused Gadolinium based contrast agents. A few publications from over twenty years ago used MRI or single-voxel NMR spectroscopy to assess D2O (or 17O water) for tissue perfusion. However, these studies never investigated the application of D2O MRI to altered permeability. Our current study explore the dynamic direct D2O MRI to map tissue permeability, and applied it to map the water exchange in rodent vitreous.
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