Abstract #5027

Performance of ultrafast DCE-MRI for diagnosis of prostate cancer

Aritrick Chatterjee¹, Dianning He^1,2, Xiaobing Fan¹, Shiyang Wang¹, Teodora Szasz³, Ambereen Yousuf¹, Federico Pineda¹, Tatjana Antic⁴, Melvy Mathew¹, Gregory S Karczmar¹, and Aytekin Oto¹

¹Department of Radiology, University of Chicago, Chicago, IL, United States, ²Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China, ³Research Computing Center, University of Chicago, Chicago, IL, United States, ⁴Department of Pathology, University of Chicago, Chicago, IL, United States

This study aimed to test high temporal resolution DCE- MRI for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). High temporal resolution (~2.2s) was achieved by modestly decreasing spatial resolution, increasing sensitivity encoding and partial Fourier factors. Our results show that PCa had significantly faster signal enhancement and washout rates than normal tissue. DCE-MRI with higher temporal resolution may capture clinically useful information for PCa diagnosis that would be missed by low temporal resolution DCE-MRI. This new information could improve the performance of mpMRI in prostate cancer detection.

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