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Abstract #5038

Compositional assessment of low-grade cartilage lesions using T2 mapping at 3 and 7 Tesla MRI: a one year follow-up study

Vladimir Juras1,2, Markus Schreiner3, Didier Laurent4, Stefan Zbyn5, Vladimir Mlynarik1, Pavol Szomolanyi1, Celeste Scotti4, Joerg Goldhahn4, Harry Haber4, Ewa Kubiak4, Stefan Marlovits6, Rahel Heule7, Oliver Bieri7, Ivan Frollo8, and Siegfried Trattnig1,9

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Imaging Methods, Institute of Measurement Science, Bratislava, Slovakia, 3Department of Orthopedics, Medical University of Vienna, Vienna, Austria, 4Novartis Institutes for Biomedical Research, Basel, Switzerland, 5Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 6Department of Traumatology, Medical University of Vienna, Vienna, Austria, 7Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 8Slovak Academy of Sciences, Institute of Measurement Science, Bratislava 4, Slovakia, 9Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

T2 maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in five time points (baseline, 8 days, 3, 6 and 12 months). For the T2 mapping, a 3D triple echo steady state sequence which is capable of delivering high quality high-resolved T2 maps at ultra-high field MRI was used. We observed a significant decrease in T2 values at 3T over time in superficial zone of the cartilage defect. There was no statistically significant change at 7T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.

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