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Abstract #5039

A composite metric R2-R1ρ measures an incomplete anisotropic R2 of human femoral cartilage at 3T

Yuxi Pang1, Riann M Palmieri-Smith2,3, and Thomas L Chenevert1

1Radiology, University of Michigan, Ann Arbor, MI, United States, 2Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States, 3School of Kinesiology, University of Michigan, Ann Arbor, MI, United States

The composite relaxation metric R2-R, a potential MR imaging biomarker for detecting early cartilage degeneration, was shown as an incomplete orientation-dependent R2 at 3T. Both R2 and R mappings of femoral cartilage were performed on two subjects, and the constructed composite metrics were compared to the anisotropic R2 values that were extracted from a single 3D T2W dataset using a newly developed method. The preliminary results demonstrated that the orientation-dependent information derived from two completely different methods was comparable, implying that the diagnostically most relevant information in knee or other joint cartilage could be easily and efficiently obtained.

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