Abstract #5039

A composite metric R2-R1ρ measures an incomplete anisotropic R2 of human femoral cartilage at 3T

Yuxi Pang¹, Riann M Palmieri-Smith^2,3, and Thomas L Chenevert¹

¹Radiology, University of Michigan, Ann Arbor, MI, United States, ²Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States, ³School of Kinesiology, University of Michigan, Ann Arbor, MI, United States

The composite relaxation metric R₂-R_1ρ, a potential MR imaging biomarker for detecting early cartilage degeneration, was shown as an incomplete orientation-dependent R₂ at 3T. Both R₂ and R_1ρ mappings of femoral cartilage were performed on two subjects, and the constructed composite metrics were compared to the anisotropic R₂ values that were extracted from a single 3D T2W dataset using a newly developed method. The preliminary results demonstrated that the orientation-dependent information derived from two completely different methods was comparable, implying that the diagnostically most relevant information in knee or other joint cartilage could be easily and efficiently obtained.

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