Abstract #5047

T1ρ dispersion assessment of articular cartilage in a rabbit ACL transection model

Abdul Wahed Kajabi^1,2, Victor Casula^1,2, Simo Ojanen^1,3, Mikko Finnilä^1,3, Rami K. Korhonen³, Walter Herzog⁴, Simo Saarakkala^1,2, Mikko J. Nissi³, and Miika T. Nieminen^1,2,5

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ³Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ⁴Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, ⁵Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

T1ρ dispersion measurements were performed to assess early degenerative changes in articular cartilage in an experimentally induced anterior cruciate ligament transection (ACLT) rabbit model. T2 and T1ρ with spin-lock field amplitudes of 500 Hz, 1 kHz and 2 kHz were measured at 9.4 T. Cartilage mechanical properties and proteoglycan content were determined using indentation testing and quantitative histology, respectively. T1ρ dispersion identified degenerative alterations in cartilage as early as two weeks after ACL transection. The dispersion parameters were statistically correlated with biomechanical properties and proteoglycan content.

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