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Abstract #5047

T1ρ dispersion assessment of articular cartilage in a rabbit ACL transection model

Abdul Wahed Kajabi1,2, Victor Casula1,2, Simo Ojanen1,3, Mikko Finnilä1,3, Rami K. Korhonen3, Walter Herzog4, Simo Saarakkala1,2, Mikko J. Nissi3, and Miika T. Nieminen1,2,5

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, 5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

T1ρ dispersion measurements were performed to assess early degenerative changes in articular cartilage in an experimentally induced anterior cruciate ligament transection (ACLT) rabbit model. T2 and T1ρ with spin-lock field amplitudes of 500 Hz, 1 kHz and 2 kHz were measured at 9.4 T. Cartilage mechanical properties and proteoglycan content were determined using indentation testing and quantitative histology, respectively. T1ρ dispersion identified degenerative alterations in cartilage as early as two weeks after ACL transection. The dispersion parameters were statistically correlated with biomechanical properties and proteoglycan content.

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