Meeting Banner
Abstract #5049

Optimizing $$$T_{1\rho}$$$ dispersion measurements for correlation time mapping in articular cartilage at 9.4 T

Hassaan Elsayed1,2,3, Stefan Zbyn1,2,3, Nina Hänninen1, Timo Liimatainen4, Mikko J. Nissi5, Miika T. Nieminen1,2,3, and Matti Hanni1,2,3

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 4Clinical Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

Correlation time ($$$\tau_c$$$) is an intrinsic property of molecules that can be probed from $$$T_{1\rho}$$$ dispersion measurement. The aim of this study was to evaluate the effect of low and high spin-lock frequencies (SLFs) on $$$\tau_c$$$ fitting and to find the optimum SLFs set within the typical clinical range. One bovine and two human cartilage samples were scanned to obtain $$$T_{1\rho}$$$ dispersion with 22 SLFs between 10 to 2500 Hz. $$$\tau_c$$$ maps were obtained by fitting Lorentzian function to different subsets of $$$T_{1\rho}$$$ dispersion. Our results show that $$$\tau_c$$$ fitting is significantly affected by low SLFs compared to high SLFs.

This abstract and the presentation materials are available to members only; a login is required.

Join Here