Abstract #5051

Orientation anisotropy of qMRI parameters in degenerated human articular cartilage

Nina Hänninen^1,2, Olli Nykänen², Mithilesh Prakash², Matti Hanni^1,3,4, Miika Tapio Nieminen^1,3,4, and Mikko Johannes Nissi²

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ³Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, ⁴Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Quantitative MR relaxation parameters have been used for evaluation of composition and structure of articular cartilage, and demonstrated to have variable sensitivity to orientation of the tissue in magnetic field. The orientation dependence of multiple relaxation parameters was assessed in human cartilage of varying degree of degeneration, and correlated with biomechanical testing. T₂ and CW-T_1ρ at 400Hz spin-lock demonstrated most clear anisotropy patterns which varied among the samples of different cartilage quality.

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