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Abstract #5051

Orientation anisotropy of qMRI parameters in degenerated human articular cartilage

Nina Hänninen1,2, Olli Nykänen2, Mithilesh Prakash2, Matti Hanni1,3,4, Miika Tapio Nieminen1,3,4, and Mikko Johannes Nissi2

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Quantitative MR relaxation parameters have been used for evaluation of composition and structure of articular cartilage, and demonstrated to have variable sensitivity to orientation of the tissue in magnetic field. The orientation dependence of multiple relaxation parameters was assessed in human cartilage of varying degree of degeneration, and correlated with biomechanical testing. T2 and CW-T at 400Hz spin-lock demonstrated most clear anisotropy patterns which varied among the samples of different cartilage quality.

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