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Abstract #5056

Improved 3D T1rho and T2 Mapping with Synovial Fluid Suppression for the Knee Cartilage on 3T

Qi Peng1, Can Wu2, Xiaojuan Li3, and Karen Sperling1

1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 2Philips Healthcare, Gainesville, FL, United States, 3Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States

T1rho and T2 values of synovial fluid are more than twenty times larger than those of the normal cartilage tissue at 3T. The potential signal contamination originated from synovial fluid within the joints adjacent to the concerned articular cartilage could be a major source of errors associated with current T1rho and T2 mapping sequences in clinical research. In this study, we presented a long-T2-selective suppression module to null synovial fluid signal while preserve cartilage signal for acquisition. Its performance in 3D continuous-wave T1rho, adiabatic T1rho, and T2 mapping sequences was evaluated in phantom and human studies.

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