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Abstract #5057

Evaluation of Resting-State BOLD MRI of Calf Muscles in Healthy Volunteers and Patients with Peripheral Arterial Disease

Shiteng Suo1, Qing Lu1, Lan Zhang2, Hui Tang1, Qihong Ni2, Suqin Li1, Haimin Mao1, Xiangyu Liu1, Jianxun Qu3, and Jianrong Xu1

1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3GE Healthcare China, Shanghai, China

BOLD MRI is a helpful imaging modality for assessing tissue oxygenation/perfusion characteristics in skeletal muscles. However, few studies have explored the utility of resting-state BOLD MRI in healthy subjects and patients with peripheral arterial disease (PAD). We conducted this study aimed at addressing this question, and results showed that (1) T2* was found to be independent of age factor in calf muscles; (2) T2* was useful for differentiating PAD patients with age-matched older healthy subjects, as well as mild-to-moderate PAD patients with severe ones; and (3) T2* correlated well with ankle-brachial index in PAD patients.

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