Abstract #5057

Evaluation of Resting-State BOLD MRI of Calf Muscles in Healthy Volunteers and Patients with Peripheral Arterial Disease

Shiteng Suo¹, Qing Lu¹, Lan Zhang², Hui Tang¹, Qihong Ni², Suqin Li¹, Haimin Mao¹, Xiangyu Liu¹, Jianxun Qu³, and Jianrong Xu¹

¹Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ²Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³GE Healthcare China, Shanghai, China

BOLD MRI is a helpful imaging modality for assessing tissue oxygenation/perfusion characteristics in skeletal muscles. However, few studies have explored the utility of resting-state BOLD MRI in healthy subjects and patients with peripheral arterial disease (PAD). We conducted this study aimed at addressing this question, and results showed that (1) T2* was found to be independent of age factor in calf muscles; (2) T2* was useful for differentiating PAD patients with age-matched older healthy subjects, as well as mild-to-moderate PAD patients with severe ones; and (3) T2* correlated well with ankle-brachial index in PAD patients.

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