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Abstract #5059

Decreasing Water T2 based on multi-TE single-voxel MRS in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Sarah Schlaeger1,2, Dominik Weidlich1, Elisabeth Klupp2, Federica Montagnese3, Marcus Deschauer4, Benedikt Schoser3, Sarah Bublitz4, Claus Zimmer2, Ernst J. Rummeny1, Jan S. Kirschke2, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, 3Friedrich-Baur-Institut, Ludwig Maximilian University, Munich, Germany, 4Department of Neurology, Technical University of Munich, Munich, Germany

Quantitative imaging techniques are emerging in the field of magnetic resonance imaging of neuromuscular diseases. Water T2 and proton density fat fraction are the most important imaging markers to assess edematous and fatty transformation in the patients’ muscle tissue. To validate the accuracy of quantitative methods 1H magnetic resonance spectroscopy can be used as a reference standard. The present study investigates water T2 of remaining muscle tissue in regions of higher proton density fat fraction in 42 patients with various neuromuscular diseases using multi-TE single-voxel MRS.

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