Abstract #5060

Effectiveness of Diffusion-Tensor Imaging adapted to chemical-shift-encoded water-fat MRI in dystrophic skeletal muscle

Sarah Keller¹, Zhiyue J. Wang², Annette Aigner³, Amir Golsari⁴, Hendrik Kooijman⁵, Gerhard Adam⁶, and Jin Yamamura⁶

¹Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Childrens’ Medical Center Dallas, Dallas, TX, United States, ³Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵MR Clinical Science, Philips Medical Systems, Hamburg, Germany, ⁶University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Diffusion tensor imaging of the skeletal muscle has been successfully applied in various conditions such as inflammation, age, and trauma. However it remains challenging in dystrophic skeletal muscle as reliable acquisition of tensor metrics is hampered due to fatty infiltration. This study aimed to assess the effectiveness of a simple clinical approach on region-of-interest localization choosing either a custom, whole muscle ROI or a selective ROI excluding areas of fatty replacement. The effect of ROI localization on tensor metrics was calculated based on mixed effect models.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.