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Abstract #5060

Effectiveness of Diffusion-Tensor Imaging adapted to chemical-shift-encoded water-fat MRI in dystrophic skeletal muscle

Sarah Keller1, Zhiyue J. Wang2, Annette Aigner3, Amir Golsari4, Hendrik Kooijman5, Gerhard Adam6, and Jin Yamamura6

1Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Childrens’ Medical Center Dallas, Dallas, TX, United States, 3Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 4Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5MR Clinical Science, Philips Medical Systems, Hamburg, Germany, 6University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Diffusion tensor imaging of the skeletal muscle has been successfully applied in various conditions such as inflammation, age, and trauma. However it remains challenging in dystrophic skeletal muscle as reliable acquisition of tensor metrics is hampered due to fatty infiltration. This study aimed to assess the effectiveness of a simple clinical approach on region-of-interest localization choosing either a custom, whole muscle ROI or a selective ROI excluding areas of fatty replacement. The effect of ROI localization on tensor metrics was calculated based on mixed effect models.

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