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Abstract #5063

Combined accelerated 4D Phase Contrast and 3D Diffusion Tensor Imaging reveals a complex relation between strain and muscle architecture in contracting leg muscles

Valentina Mazzoli1,2,3, Martijn Froeling4, Lukas M Gottwald1, Nico Verdonschot3, Melissa T Hooijmans1, Aart J Nederveen1, and Gustav J Strijkers2,5

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Orthopaedic Research Laboratory, Radboud UMC, Nijmegen, Netherlands, 4Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 5Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

Skeletal muscles are geometrically complex 3D structures, and cannot be fully characterized by 2D imaging. Therefore, a complete understanding of mechanisms of force transmission and strain development in relation to muscle architecture during contraction requires a 3D approach. We measured strain rate in the lower leg using a 4D accelerated Phase Contrast protocol and 3D muscle architecture with DTI. Our 3D strain rate data revealed a planar pattern, with one negative and one positive strain rate eigenvalue. Strain rate data combined with 3D muscle architecture, suggested a complex and heterogeneous behavior of strain development during muscle contraction.

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