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Abstract #5064

Modeling skeletal muscle perfusion through application of the continuous time random walk model to diffusion-weighted images

David Reiter1,2, Fatemeh Adelnia2, Donnie Cameron3, Christopher Bergeron2, Richard G. Spencer2, and Luigi Ferrucci2

1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2National Institute on Aging, Baltimore, MD, United States, 3Clinical Magnetic Resonance Physics, University of East Anglia, Norwich, United Kingdom

The continuous time random walk (CTRW) model provides a flexible framework for representing complex diffusive processes, allowing for smooth interpolation between sub- and super-diffusion. This work presents supporting arguments for the application of the CTRW model to the measurement of skeletal muscle perfusion. We present model fit parameters from DW images of human skeletal muscle and compare estimates of intravascular volume fraction with previously reported values obtained using intravital microscopy.

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