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Abstract #5096

In-vivo validation of water content Electrical Properties Tomography reconstructions in white matter using independent MR-EPT measurements

Stefano Mandija1, Petar I Petrov2, Jord T Vink2, Sebastian F.W. Neggers2, Peter R. Luijten1, and Cornelis A.T. van den Berg1

1Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 2Rudolf Magnus Institute for Neuroscience, UMC Utrecht, Utrecht, Netherlands

MR-Electrical Properties Tomography (MR-EPT) can provide accurate mean conductivity values in large homogeneous tissues such as the white matter, provided sufficient erosion to avoid boundary regions. Water-content-EPT (wEPT) has been recently proposed to reconstruct EPs on a voxel-to-voxel basis. However, wEPT uses an empirical model calibrated with literature EPs values, assumed correct, obtained from ex-vivo probe measurements. In this work, the validity of the model employed in wEPT is verified for white matter conductivity reconstructions by using in the wEPT model calibration the mean white matter conductivity value obtained from in-vivo MR-EPT reconstructions as an independent modality.

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