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Abstract #5108

Toward CEST MRI of renal masses: protocol optimization and first preliminary data

Shu Zhang1, Bian Li1, Joshua Greer1,2, Ananth J Madhuranthakam1,3, Jochen Keupp4, Ivan E Dimitrov3,5, Robert E Lenkinski1,3, Ivan Pedrosa1,3, and Elena Vinogradov1,3

1Radiology Department, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Biomedical Engineering, University of Texas Dallas, Dallas, TX, United States, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Philips Research, Hamburg, Germany, 5Philips Healthcare, Gainesville, FL, United States

Chemical Exchange Saturation Transfer (CEST) MRI is emerging as a tool for the studies of human malignancy. However, the translation of CEST into a successful tool for renal cancer characterization has been slow and hampered by technical difficulties associated with body imaging, such as motion, contaminating lipid signals and increased B­0 ingomogeneity. Here we optimize CEST protocol for characterization of renal masses and demonstrate CEST measurements are feasible in kidneys using combination of motion synchronization, post-processing registration and lipid artifact removal. In addition, first Renal Cell Carcinoma patient CEST-mDixon data is shown and imaging results are correlated with the pathology.

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