Abstract #5116

Detection of the accumulation of mannitol in rat brains using CEST MRI

Jing Liu¹, Chengyan Chu¹, Lin Chen¹, Jia Zhang¹, Rohit Kumar Srivatava^1,2, Piotr Walczak^1,2, Jiadi Xu¹, Peter van Zijl¹, Miroslaw Janowski^1,2, and Guanshu Liu¹

¹Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Mannitol is a clinically widely-used osmotic agent. Accumulation of mannitol in the interstitium of the brain, however, can cause severe adverse effects. Here we used CEST MRI to detect mannitol directly through its inherently carried exchangeable hydroxyl protons. After comprehensively characterizing the CEST properties of mannitol in vitro, we demonstrated that the intra-arterial infusion of mannitol at an excess dose led to a significantly elevated CEST signal at 0.9 ppm, indicating that CEST MRI has great clinical potential to be used as a monitoring tool for mannitol treatment.

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