Mannitol is a clinically widely-used osmotic agent. Accumulation of mannitol in the interstitium of the brain, however, can cause severe adverse effects. Here we used CEST MRI to detect mannitol directly through its inherently carried exchangeable hydroxyl protons. After comprehensively characterizing the CEST properties of mannitol in vitro, we demonstrated that the intra-arterial infusion of mannitol at an excess dose led to a significantly elevated CEST signal at 0.9 ppm, indicating that CEST MRI has
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