The purpose of this study is to clarify the relationship between APT and NOE effects derived from CPE fitting of the human brain on a 3 T MR scanner. CEST imaging with different B1 values of the brain was performed in healthy subjects. The mean NOE values of white matter at 0.5 µT were higher than all regions (P < 0.05). CPE-spectrum shows greater sensitivity for both APT and NOE peaks than conventional Z-spectrum and MTRasym. It is found that NOE imaging on a 3.0 T scanner is sensitive on low-B1 power regardless of the CEST fitting process.