Abstract #5117

Nuclear Overhauser enhancement effect of low $$$B_{1}$$$ power CEST RF in human brain at 3.0 T

Yuki Kanazawa¹, Masafumi Harada¹, Mitsuharu Miyoshi², Ikuho Kosaka³, Kotaro Baba³, Hiroaki Hayashi¹, and Yuki Matsumoto⁴

¹Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, ²Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, ³School of Health Sciences, Tokushima University, Tokushima, Japan, ⁴Graduate school of Health Science, Tokushima University, Tokushima, Japan

The purpose of this study is to clarify the relationship between APT and NOE effects derived from CPE fitting of the human brain on a 3 T MR scanner. CEST imaging with different B₁ values of the brain was performed in healthy subjects. The mean NOE values of white matter at 0.5 µT were higher than all regions (P < 0.05). CPE-spectrum shows greater sensitivity for both APT and NOE peaks than conventional Z-spectrum and MTR_asym. It is found that NOE imaging on a 3.0 T scanner is sensitive on low-B₁ power regardless of the CEST fitting process.

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