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Abstract #5119

Toward Safer Monitoring of Glucose Transport in a Rat Brain Tumor Necrosis using 3-O-Methyl-Glucose Chemical Exchange-sensitive Spin-Lock Magnetic Resonance Imaging

Julius Juhyun Chung1,2, Moon-Sun Jang3,4, Geun Ho Im3,4, Wonmin Choi1,5, Tao Jin6, Seong-Gi Kim1,2,5, and Jung Hee Lee1,2,4,5

1Center for Neuroscience Imaging Research, Institute for Basic Science SKKU, Suwon, Republic of Korea, 2Samsung Advanced Insitute for Health Sciences and Technology, SKKU, Seoul, Republic of Korea, 3Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul, Republic of Korea, 4Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 5Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 6Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Glucose exchange-sensitive spin lock imaging has been shown to have promise in monitoring glucose uptake with reasonable sensitivity. There are design choices that can be made in such an experiment such as whether to use an analog for better sensitivity and how to establish an efficient spin-lock. We examine metabolic uptake of a rat brain tumor with necrosis using 3-O-methyl-glucose, a safer glucose analog than 2DG, and examine differences between using an adiabatic pulse and a paired self-compensated pulse with lower peak power. Both pulses demonstrated delayed uptake in the infarcted tumor region although with higher sensitivity using adiabatic pulses.

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