Glucose exchange-sensitive spin lock imaging has been shown to have promise in monitoring glucose uptake with reasonable sensitivity. There are design choices that can be made in such an experiment such as whether to use an analog for better sensitivity and how to establish an efficient spin-lock. We examine metabolic uptake of a rat brain tumor with necrosis using 3-O-methyl-glucose, a safer glucose analog than 2DG, and examine differences between using an adiabatic pulse and a paired self-compensated pulse with lower peak power. Both pulses demonstrated delayed uptake in the infarcted tumor region although with higher sensitivity using adiabatic pulses.
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